The Mutagenic Constituents of Rubia tinctorum.
نویسندگان
چکیده
منابع مشابه
Comparative Studies of Rubia Cordifolia Linn. and Rubia Tinctorum Linn (rubiaceae)*
Comparative morphological microscopical and phytochemical studies of root and stem parts of R. cordifolia and R. tinctorum L. (Rubiaceae) have been carried out.
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Four new naphthohydroquinones, rubinaphthins A (1), B (2), C (3), and D (4), together with 11 known compounds were isolated and characterized from the roots of Rubia yunnanensis. The structures of 1-4 were elucidated by spectral analysis and chemical transformation.
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Activity-directed isolation of the methylene chloride fraction of the roots of Rubia cordifolia L. resulted in the identification of a new epoxymollugin (3) and eight known compounds (1, 2, 4-9). The structures of the compounds were elucidated from chemical and spectroscopic evidence. In addition, their topoisomerase I and II inhibitory activities and cytotoxicities were measured.
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Article history Received 11 June 2011 Revised 24 July 2011 Accepted 8 December 2011 Available online 30 April 2012 Rubia tinctorum L. (Rubiaceae) root is traditionally used in Morocco for treating the gastro-intestinal diseases. The aim of the present study was to assess the antispasmodic effects of the aqueous extract of this root plant (AR) on rodents.The effect of the AR on spontaneous contr...
متن کاملIsolation and extraction of ruberythric acid from Rubia tinctorum L. and crystal structure elucidation.
Madder (Rubia tinctorum L.) has been exploited as a dye throughout history. The roots of the plant are very rich in the highly coloured glycosidic compounds ruberythric acid and lucidin primeveroside, alongside the corresponding aglycons which can be readily formed by deglycosylation, particularly during extraction. Supported by (1)H and (13)C NMR data, the conclusive X-ray crystal structure of...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1992
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.40.1504